Project detail

Mucoadhesive injectable hydrogel carriers enriched with pro-healing protein for hard-to-heal oral wounds

Duration: 01.01.2022 — 31.03.2023

Funding resources

Evropská unie - Interní grantová soutěž

- whole funder (2022-01-01 - 2022-12-31)

On the project

More extensive wounds at the oral mucosa site, especially after resection of oral tumors, are hard-to-heal. In this project, a bioresorbable, thermosensitive, and injectable copolymer based on lactic and glycolic acid and poly(ethylene glycol) PLGA-PEG-PLGA will be modified to promote mucoadhesive properties. The hydrogel will be further enriched with stabilized liposomal pro-healing protein (FGF2-STAB). The chemical structure, rheological properties, hydrolytic stability, and protein release of such a drug delivery system will be evaluated.

Mark

CEITEC VUT-K-22-7779

Default language

English

People responsible

Dzurov Matej, Ing. - fellow researcher
Sevriugina Veronika, Ing. - fellow researcher
Kadlecová Zuzana, Ing. - principal person responsible

Units

Central European Institute of Technology BUT
- (2022-01-01 - 2022-12-31)

Results

KADLECOVÁ, Z.; VOJTOVÁ, L. Mucoadhesive injectable hydrogel carriers enriched with encapsulated pro-healing protein for hard-to-heal oral wounds. Czech Chemical Society Symposium Series. Czech Chemical Society, 2022. p. 19-20. ISSN: 2336-7210.
Detail

KADLECOVÁ, Z.; DZUROV, M.; LYSÁKOVÁ, K.; VOJTOVÁ, L. Mucoadhesive Injectable Hydrogel Enriched with Encapsulated Pro-healing Protein for Hard-to-heal Oral Wounds Treatment. 32nd Annual Conference of the European Society for Biomaterials. France: Marjorie Dufaud, Member of the BIOMAT Young Researchers Board, 2022. p. 383-383.
Detail

SEVRIUGINA, V.; KADLECOVÁ, Z.; VOJTOVÁ, L. The effect of liposomal pro-healing protein on the rheological properties of mucoadhesive injectable hydrogel. Program and Book of Abstracts. Materials Research Society of Serbia, 2022. p. 156-156. ISBN: 978-86-919111-7-1.
Detail

Responsibility: Kadlecová Zuzana, Ing.